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 IU Trident Indiana University

Support for the Consortium for Top Down Proteomics

PIs: Neil L. Kelleher and Nicolas L. Young

National Center for Genome Analysis Support (NCGAS),UITS Research Technologies, research made possible by Mason, Scholarly Data Archive (SDA) 

Research Storage Group, UITS Research Technologies

Protonomics Site Image

Figure 1. The CTDP provides a web-based repository for their discoveries, but the raw data supporting these discoveries is much too massive to be stored on a commodity web server. RT provides free storage for these public and valuable data files.

The Consortium for Top Down Proteomics (CTDP) is a group of scientists from around the world focused on developing a unique approach to measuring modified proteins in complex mixtures such as blood or tissue samples. NCGAS and UITS Research Technologies have been supporting the CTDP's efforts with bioinformatic support for their recently published first pilot project (http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300438/abstract) and by providing free archive space for the raw mass spectrometer data files that support entries in their Proteoform Repository.

An emerging issue with big data in life sciences is how to make the observations supporting a discovery available over time. This is particularly true with proteomic data where the samples and measurement platform can be extremely difficult to recreate. By storing their raw data files publicly on Indiana University's ScholarWorks archive, the CTDP can focus on perfecting their scientific technique and not worry about the technical issues associated with maintaining electronic archives.

NCGAS provides bioinformatic support for developing data analytic techniques used by the CTDP, but more importantly NCGAS and the Research Storage group (which oversees the Scholarly Data Archive) provide facilities for long-term archiving of the data sets that the CTDP wishes to share with researchers around the world


The National Center for Genome Analysis Support supports life science research on the national cyberinfrastructure, enabling the US biological research community to analyze, understand, and make use of the vast amount of genomic information now available. NCGAS focuses particularly on transcriptome- and genome-level assembly, phylogenetics, metagenomics/transcriptomics and community genomics. 

The Research Storage group manages and supports the Scholarly Data Archive and the Research File System, providing advanced and reliable storage services for Indiana University researchers.

NSF GSS Codes:

Primary Field: Genetics 610 - Genome Sciences/Genomics

Secondary Field: Computer Science 401 - Computer Systems Analysis