Excited States via Coupled Cluster Fragmentation to Solve Keto/Enol Tautomerization Ratios of Artificial DNA
Project Leads: PI: Dr. Nigel Richards (Department of Chemistry & Chemical Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA) Lead: Dr. Robert Molt Jr. (Department of Chemistry & Chemical Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA) and Dr. Jason Byrd (Quantum Theory Project, University of Florida, Gainesville, FL, 32611)
Research made possible by: High Performance Systems (HPS), Scientific Applications and Performance Tuning (SciAPT; Big Red II supercomputer
|Artificial DNA is a promising technology to cure genetic diseases, already in use for HIV treatment. The basic premise is simple: if a person's normal DNA lacks what is necessary to function properly, rather than adjust that person's DNA, add a separate artificial DNA that can do the job. However, different models of artificial DNA suffer from a low chemical stability. We have investigated how to quantify the stability of artificial DNA, and proposed chemical modifications to make it last much longer (ideally, over a person's entire life).
We have solved several long-standing problems in chemistry and physics simultaneously:
The mission of the Scientific Applications and Performance Tuning (SciAPT) group is to deliver and support software tools that promote effective and efficient use of IU's advanced cyberinfrastructure which, in turn, improves research and enables discoveries.
NSF GSS Codes:
Primary Field: Clinical Medicine (721) Clinical/Medical Laboratory Science and Allied Professions and Molecular Medicine
Secondary Fields: Chemistry (202) Organic Chemistry and Preventive Medicine and Community Health (712) Health/Medical Physics